gtex

Sarah Urbut, Kushal Dey + Matthew Stephens group

Example top eQTLs: T statistics in 44 tissues

Method Outline

Multi-tissue eQTL mapping is basically trying to cluster these (noisy!) profiles

Tissue-strong eQTLs: Testis

Tissue-strong eQTLs: Whole-Blood

Tissue-strong eQTLs: LCLs

Also many “tissue-consistent” eQTLs

Method Outline

That U is still with us…

But tissue-specific dominated by a few tissues…

Lots of sharing, but similar tissues share more

Maybe some false positives?

Tissue-specific eQTLs don’t (usually) show Tissue-specific expression

Things to worry about: Correlations between tissues

Summary

(Thanks to Karl Broman and his R/qtlcharts package)